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ABSTRACT
| Predictors of Seizure Control among Adolescents and Youths with Epilepsy in Sokoto: A Retrospective Chart Review |
| Ibrahim A. Ogunyinka1*, Patrick O. Erah2, Stella F. Usifoh2, Kazeem A. Oshikoya3, Murtala M. Ahmad4, Sunday A. Adebisi5, Liman M. Usman1, Emeka I. Oforkansi1, Fahidat J. Qamarudeen1 |
| Background: Epilepsy is a common, serious and rising neurological disorder affecting all age groups globally with its burden disproportionately more on patients in developing countries and those being offered transition care. Optimal antiseizure medication (ASM) pharmacotherapy is the cornerstone of epilepsy care among transition-aged individuals with epilepsy. Aim: The study aimed to determine the predictors of seizure control outcomes among those transitioning from childhood care to adult care. Materials/Methods: This was a seven-year review of epilepsy care among patients aged between 15- and 24-years seeking care at the Adult Neurology Clinics of Usmanu Danfodiyo University Teaching Hospital, Sokoto and Federal Neuropsychiatric Hospital, Kware, Sokoto. This multi-site audit assessed case files of eligible patients receiving ASMs between January 2018 and October 2024. Data analyses were conducted using SPSS version 26.0 and all associations were considered significant at p≤0.05. The study was approved by the Health Research and Ethics Committees of the study centres. Results: A total of 1107 adolescents and youths with epilepsy (males: 582; 52.6%; median (interquartile range) age and age at first seizure: 19 (4) and 15 (8) years; generalized-onset seizure: 824, 74.4%) were studied. Carbamazepine monotherapy was the commonest therapeutic regimen (957; 86.4%) with 606 (54.7%) of the study cohort having their seizure controlled. The major predictors of this seizure control are ASM adherence [odds ratio: 26.345 (95% confidence interval: 19.224-37.185), p-value: 0.0005]; participant's negative history of febrile seizure [odds ratio: 2.377 (95% confidence interval: 1.126-5.019), p-value: 0.023] and absence of comorbidities [odds ratio: 1.966 (95% confidence interval: 1.116-3.462), p-value: 0.019]. Conclusion: The major predictors of effective seizure control among the study cohort were adherent to the ASM regimen, having neither history of febrile seizure nor comorbidity. |
| 10.51658/ABMS.202561.8 |
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