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ABSTRACT
| Independent of the Time-To-Peak of Forward Pressure Wave, Pulse Wave Velocity Correlates Better with Hypertensive Heart Failure Phenotype with a Preserved Ejection Fraction |
| Adamu J Bamaiyi¹,³* Frank B Mojiminiyi², Basiru Shuaibu¹, Ridwanullah A Abubakar¹, Ebenezer A Morolahun¹, Keneilwe N Mmopi⁴, Nafisat Abdulazeez⁵ |
| Background: Heart failure with a preserved ejection fraction (HFpEF) and heart failure with a reduced ejection fraction (HFrEF) exist in equal proportions. However, which of these phenotypes associate more with pulse wave velocity (PWV), a measure of extent of aortic wall stiffness, which is an important mechanism of hypertensive heart diseases, is not clearly understood. Materials/methods: Anthropometries and conventional blood pressure (BP) were measured by standard procedures. Central BP was measured using a validated, non-invasive pulsepen, interfaced with a computer on HFpEF (n=73), HFrEF (n =76) patients and normal volunteers (n =118). In a left parasternal long-axis view, M-mode echocardiography was also done on the participants. The slopes (β- coefficient) of the relationship of PWV and times to peak of forward wave (fT) and backward wave (bT) and the corresponding coefficient of determinations (R2) were recorded. Results: In all sub-groups, the central systolic BPs and pulse pressures (PP) were significantly lower than the corresponding conventional systolic BPs and PP, intra-groups (p <.05). Although, the PWV for the HFrEF was higher than that for HFpEF, the bT of the HFpEF was shorter (p =.001). Furthermore, when the β-coefficient of PWV and the bT were assessed, the values obtained were 0.67, 0.47 and -0.31 (P <.05), for the HFpEF, HFrEF and the normal volunteers, respectively. Indeed, the slopes were compared among the sub-group, after adjusting for the effect of the fT on bT, the HFpEF sub-group showed better relationship compared to the HFrEF or the normal volunteers (0.039, 0.020 and -0.002, P <.001). Conclusions: HFpEF in the present data is significantly characterized by higher PWV, early return of bT and showed a better slope of the relationship between the 2 parameters, beyond that exhibited by the HFrEF. |
| 10.51658/ABMS.202561.1 |
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