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ABSTRACT
| Prevalence and Susceptibility patterns of Gram Negative Uropathogens among Adult Patients Attending Federal Medical Centre Azare, Bauchi State, NigeriaCentre Azare, Bauchi State, Nigeria |
| Mairo U Kadaura¹*, Abubakar Jibril¹, Kellu B. Ali², Abdulkarim Abdullahi³, Uchenna S. Ezankwa⁴, Sabiu Aminu⁵, Musa A. Garbatti⁶ |
| Background: Urinary tract infection (UTI) is considered a major public health problem of global concern. It is caused by bacteria in about 95% of cases, mainly gram-negative. It is the second most common bacterial infection affecting individuals of all ages. The emergence of antimicrobial resistance in uropathogens, especially gram-negative, may lead to poor treatment outcomes. Materials and Methods: This cross-sectional study was carried out over three months (November 2023 to January 2024), with a focus on the identification of gram-negative bacterial pathogens causing UTI and the evaluation of their antibiogram. In total, 394 fresh urine samples were collected from individuals with suspected infection and inoculated on recommended media. Isolation and identification of the bacterial strains were performed using standard microbiological protocols. Antibiotic susceptibility was carried out following CLSI guidelines. Results: Among the 394 tested specimens, 78 (19.8%) had significant bacterial growth 52(13.2%) of the strains were isolated from female patients and the age group 28-37 years had the highest prevalence of 35.9%. The frequently identified isolates were Escherichia coli (38.5%), followed by Klebsiella spp (23.1%) and Pseudomonas aeroginosa (11.5%). The isolates showed considerable resistance to all the antibiotics tested. The highest resistance was recorded for ceftriaxone (89.3%) and amoxicillin-clavulanate (76%), while resistance was the least for imipenem (16%). Conclusion: The current high rate of MDR gram-negative bacterial infections among adult patients in the studied area is alarming. Therefore, calls for an urgent review of the treatment of urinary tract infections among adults in Federal Medical Center Azare. Regular surveillance and antibiotic stewardship policies should be instituted to improve practices and clinical outcomes |
| 10.51658/ABMS.202452.5 |
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