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Publication Title : Assessment of Vitamin D in Sickle Cell Anaemia Patients
Author(s) : Umar Aminu Abdullahi
Abstract : Background: Sickle Cell Disease (SCD) is a group of disorders of haemoglobin (Haemoglobinopathies) arising from inheritance of abnormal haemoglobin S (HbS) with consequent clinical presentation. It arises from a single-base change in the DNA where adenine is replaced by thymine this lead to the substitution of glutamic acid by valine at position 6 of the β-globin chain which leads to the production of a defective form of haemoglobin (Hb) and HbS. Methods: Literature search was conducted from recognized online databases and libraries. Results: Sickle Cell Anaemia (SCA) is the prototype and severe form of Sickle cell disease, a major public health problem in sub saharan Africa with high morbidities like bony alterations and bone fragility especially in those with vitamin D deficiency. Vitamin D (VD) is one of the nutritional concern for individuals with SCA, the outcomes of vitamin D deficiency are ricket and osteoporosis, in addition, VD enhances innate immunity and suppressing the excessive expression of proinflammatory cytokines a correlation between COVID-19 susceptibility. Conclusion: Sickle cell anaemia patients have hypocalcaemic tendency associated with supranormal parathyroid hormone (PTH) and alkaline phosphatase (ALP), and imply impaired intestinal absorption of calcium and vitamin D leading to disturbed calcium metabolism which might contribute to the skeletal changes seen in sickle cell anaemia. This review article focuses on assessment of vitamin D in sickle cell anaemia patients. Keywords: sickle cell anaemia, vitamin D, COVID-19, Alkaline phosphatase.
DOI : 10.51658/ABMS.202122.13
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